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books
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Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R: Order-Restricted Analysis of Microarray Data
Edited by Dan Lin, Edited by Ziv Shkedy, Edited by Daniel Yekutieli, Edited by Dhammika Amaratunga, Edited by Luc Bijnens
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normal price: R 1 707.95
Price: R 1 621.95
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| book description |
This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include: •            Multiplicity adjustment •            Test statistics and procedures for the analysis of dose-response microarray data •            Resampling-based inference and use of the SAM method for small-variance genes in the data •            Identification and classification of dose-response curve shapes •            Clustering of order-restricted (but not necessarily monotone) dose-response profiles •            Gene set analysis to facilitate the interpretation of microarray results •            Hierarchical Bayesian models and Bayesian variable selection •            Non-linear models for dose-response microarray data •            Multiple contrast tests •            Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.
| product details |
Normally shipped |
Publisher | Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Published date | 26 Aug 2012
Language |
Format | Paperback / softback
Pages | 282
Dimensions | 235 x 155 x 0mm (L x W x H)
Weight | 0g
ISBN | 978-3-6422-4006-5
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Normal Price | R 2 114.95
Price | R 2 008.95
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