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Synthesis of Aromatic Compounds

By (author) Victor Snieckus, By (author) Mieczyslaw Makosza

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Written by two pioneers in the field, this is the first book to collate proven concepts for the synthesis of complex aromatics found in natural products, heterocycles, pharmaceuticals, agrochemicals, and organic materials. The authors review current methods of aromatic substitution, with a focus on directed ortho metalation (DoM) and replacement of hydrogen with nucleophilic agents (SNArH). They also provide retrosynthetic analysis schemes and numerous practical examples throughout the book. With its typical reaction procedures and tips for choosing optimum conditions for successful syntheses, this is an invaluable guide for (future) organic and synthetic chemists in pharmaceutical and agrochemical companies.

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528 pages
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