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Drug Discovery and Design Using Natural Products

Edited by Jorddy Neves Cruz

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Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to usingnatural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.

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Bonsai Success in Southern Africa

Carl Morrow
Paperback / softback
160 pages
was: R 320.95
now: R 288.95
Stock is usually dispatched in 6-12 days from date of order

In this uniquely Southern African book, Carl Morrow and Keith Kirsten guide readers step by step into the magical realms of bonsai as a hobby, horticultural practice and art form.

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Fifteen Dogs

AndrÃ© Alexis
Paperback / softback
176 pages
was: R 280.95
now: R 252.95
Available from overseas. Dispatched in aprox 4-8 weeks as local supplier is out of stock

A pack of dogs are granted the power of human thought - but what will it do to them? A surprising and insightful look at the beauty and perils of consciousness.

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The Ballerina and the Bull: Anarchist Utopias in the Age of Finance

Johanna Isaacson
Paperback / softback
288 pages
was: R 306.95
now: R 275.95
This title will take longer to obtain, and should be delivered in 6-8 weeks

Our moment has seen the resurgence of an anarchist sensibility, from the uprisings in Seattle in 1999 to the Occupy movement of 2011.

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