| book details |

Precision Medicine in Neurodegenerative Disorders: Part II: Volume 193

Volume editor Alberto J. Espay

This book is currently unavailable. Enquire to check if we can source a used copy

| enquire |

| book description |

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193Â in the Handbook of Clinical Neurology deals with the ""How"" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinksÂ animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision ""medicine""â€“matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

| product details |

| other options |

| back |

| your trolley |

To view the items in your trolley please sign in.

| sign in |

| specials |

The Coming Wave: AI, Power and Our Future

Mustafa Suleyman
Paperback / softback
352 pages
was: R 295.95
now: R 265.95
Stock is usually dispatched in 6-12 days from date of order

| more |

| add to trolley |

The Memory Collectors: A Novel

Dete Meserve
Paperback / softback
320 pages

Enquiries only

| more |

| enquire |

The Colonialist: The Vision of Cecil Rhodes

William Kelleher Storey
Paperback / softback
528 pages
was: R 425.95
now: R 382.95
Usually dispatched in 6-12 days

This first comprehensive biography of Cecil Rhodes in a generation illuminates Rhodesâ€™s vision for the expansion of imperialism in southern Africa, connecting politics and industry to internal development, and examines how this fueled a lasting, white-dominated colonial society.

| more |

| add to trolley |

Survive the AI Apocalypse: A guide for solutionists

Bronwyn Williams
Paperback / softback
232 pages
was: R 340.95
now: R 306.95
Stock is usually dispatched in 6-12 days from date of order

Look around you is anything real or normal any more? News, images and videos created by AI are everywhere.

| more |

| add to trolley |